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Generation of Multi-Scale Vascular Network System within 3D Hydrogel using 3D Bio-Printing Technology.利用3D生物打印技术在3D水凝胶中生成多尺度血管网络系统
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利用热响应性牺牲微纤维在明胶水凝胶内构建三维微血管网络

Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers.

作者信息

Lee Jung Bok, Wang Xintong, Faley Shannon, Baer Bradly, Balikov Daniel A, Sung Hak-Joon, Bellan Leon M

机构信息

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.

Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.

出版信息

Adv Healthc Mater. 2016 Apr 6;5(7):781-5. doi: 10.1002/adhm.201500792. Epub 2016 Feb 4.

DOI:10.1002/adhm.201500792
PMID:26844941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4828275/
Abstract

A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.

摘要

使用热响应性牺牲性聚（N-异丙基丙烯酰胺）微纤维制备了一种三维微血管化明胶水凝胶。类似毛细血管的微血管网络允许培养基在整个厚厚的水凝胶中持续灌注，并显著提高了高密度封装在凝胶中的人新生儿真皮成纤维细胞的活力。