Sucha Lenka, Tomsik Pavel
Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
Planta Med. 2016 Mar;82(5):379-87. doi: 10.1055/s-0042-100810. Epub 2016 Feb 4.
Steroidal glycoalkaloids present in Solanaceae are toxic compounds biosynthesised for the protection of the plants. However, many health benefits of these compounds have been reported so far. One of their promising targets might be cancer, as demonstrated in a large number of studies. However, the main mechanism of action seems to be unclear. It could include the induction of apoptosis or trigger a necrosis with a subsequent inflammatory response. The relatively high systemic toxicity of steroidal compounds is another effect that must be taken into account in anticancer research. The main aim of this work was to summarise the recent progress in the investigation of the mechanisms of their antitumour action and to discuss their potential.
茄科植物中存在的甾体糖苷生物碱是为保护植物而生物合成的有毒化合物。然而，迄今为止已报道了这些化合物的许多健康益处。正如大量研究所表明的那样，它们有前景的靶点之一可能是癌症。然而，其主要作用机制似乎尚不清楚。它可能包括诱导细胞凋亡或引发坏死并随后产生炎症反应。甾体化合物相对较高的全身毒性是抗癌研究中必须考虑的另一个因素。这项工作的主要目的是总结甾体糖苷生物碱抗肿瘤作用机制研究的最新进展，并讨论它们的潜力。
