泊洛沙姆188对镰状细胞贫血症患者红细胞膜特性的影响。
Effects of Poloxamer 188 on red blood cell membrane properties in sickle cell anaemia.
作者信息
Sandor Barbara, Marin Mickaël, Lapoumeroulie Claudine, Rabaï Miklos, Lefevre Sophie D, Lemonne Nathalie, El Nemer Wassim, Mozar Anaïs, Français Olivier, Le Pioufle Bruno, Connes Philippe, Le Van Kim Caroline
机构信息
University of Pecs Medical School, Pecs, Hungary.
Inserm UMR_S1134, Paris, France.
出版信息
Br J Haematol. 2016 Apr;173(1):145-9. doi: 10.1111/bjh.13937. Epub 2016 Feb 5.
Vaso-occlusive crisis (VOC) is the main acute complication in sickle cell anaemia (SS) and several clinical trials are investigating different drugs to improve the clinical severity of SS patients. A phase III study is currently exploring the profit of Velopoloxamer in SS during VOCs. We analysed, in-vitro, the effect of poloxamer (P188) on red blood cell (RBC) properties by investigating haemorheology, mechanical and adhesion functions using ektacytometry, microfluidics and dynamic adhesion approaches, respectively. We show that poloxamer significantly reduces blood viscosity, RBC aggregation and adhesion to endothelial cells, supporting the beneficial use of this molecule in SS therapy.
血管闭塞性危机（VOC）是镰状细胞贫血（SS）的主要急性并发症，多项临床试验正在研究不同药物以改善SS患者的临床严重程度。一项III期研究目前正在探索维洛泊洛沙姆在VOC期间对SS患者的疗效。我们在体外通过分别使用激光衍射血细胞分析仪、微流控技术和动态黏附方法研究血液流变学、机械功能和黏附功能，分析了泊洛沙姆（P188）对红细胞（RBC）特性的影响。我们发现泊洛沙姆可显著降低血液黏度、红细胞聚集以及与内皮细胞的黏附，这支持了该分子在SS治疗中的有益应用。
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