[Diagnosis and treatment of rubomycin-induced heart lesions in children with leukemia].

Clinical, electrocardiographic and ultrasonic investigations of the cardiovascular system were conducted in 64 children, suffering from leukemia for more than two years, and who received daunorubicin, from 8 to 64 mg/kg, during polychemotherapy. Cardiac changes have been detected in 42 of them. Three stages of daunorubicin-induced lesions of the cardiovascular system have been distinguished. The effectiveness of cardiotropic therapy in this group of patients has been evaluated. Recommendations have been given for the use of functional methods of heart investigation for early detection of toxic heart lesions during treatment with daunorubicin.