Reese G, Trompelt J, Becker W M, Schlaak M
Forschungsinstitut Borstel, Medizinische Klinik, Laborgruppe Allergologie.
Immun Infekt. 1989 Oct;17(5):165-8.
IgG-subclass reactivities to Micropolyspora faeni of farmer's lung patients and exposed persons were investigated. Additionally, specific IgG and IgE antibodies of patients suffering from IgE-mediated allergy and extrinsic allergic alveolitis to Aspergillus fumigatus and allergic bronchopulmonary aspergillosis (ABPA) were examined. Antibody reactivities of patients were compared with reactivities of monoclonal antibodies raised against M. faeni and A. fumigatus, respectively. The results indicate a special importance of specific IgG2 reactivity for serologic diagnosis. Monoclonal antibodies raised against M. faeni and A. fumigatus recognize components which induce antibody production in patients as well. Reactivities of monoclonal antibodies with different batches of A. fumigatus extract show the variability of these antigen preparations and illustrate the need for standardization.
研究了农民肺患者和暴露人群针对嗜热放线多孢菌的IgG亚类反应性。此外，还检测了IgE介导的过敏和外源性过敏性肺泡炎患者针对烟曲霉以及变应性支气管肺曲霉病（ABPA）的特异性IgG和IgE抗体。将患者的抗体反应性分别与针对嗜热放线多孢菌和烟曲霉产生的单克隆抗体的反应性进行了比较。结果表明特异性IgG2反应性在血清学诊断中具有特殊重要性。针对嗜热放线多孢菌和烟曲霉产生的单克隆抗体识别的成分也能诱导患者产生抗体。不同批次烟曲霉提取物与单克隆抗体的反应性显示了这些抗原制剂的变异性，并说明了标准化的必要性。
