非酒精性脂肪性肝病的定量成像生物标志物
Quantitative Imaging Biomarkers of NAFLD.
作者信息
Kinner Sonja, Reeder Scott B, Yokoo Takeshi
机构信息
Department of Radiology, University of Wisconsin, Madison, WI, USA.
Department of Diagnostic and Interventional Radiology, University Hospital Essen, Essen, Germany.
出版信息
Dig Dis Sci. 2016 May;61(5):1337-47. doi: 10.1007/s10620-016-4037-1. Epub 2016 Feb 5.
Abstract
Conventional imaging modalities, including ultrasonography (US), computed tomography (CT), and magnetic resonance (MR), play an important role in the diagnosis and management of patients with nonalcoholic fatty liver disease (NAFLD) by allowing noninvasive diagnosis of hepatic steatosis. However, conventional imaging modalities are limited as biomarkers of NAFLD for various reasons. Multi-parametric quantitative MRI techniques overcome many of the shortcomings of conventional imaging and allow comprehensive and objective evaluation of NAFLD. MRI can provide unconfounded biomarkers of hepatic fat, iron, and fibrosis in a single examination-a virtual biopsy has become a clinical reality. In this article, we will review the utility and limitation of conventional US, CT, and MR imaging for the diagnosis NAFLD. Recent advances in imaging biomarkers of NAFLD are also discussed with an emphasis in multi-parametric quantitative MRI.
摘要
传统成像方式，包括超声检查（US）、计算机断层扫描（CT）和磁共振成像（MR），通过实现对肝脂肪变性的无创诊断，在非酒精性脂肪性肝病（NAFLD）患者的诊断和管理中发挥着重要作用。然而，由于各种原因，传统成像方式作为NAFLD的生物标志物存在局限性。多参数定量MRI技术克服了传统成像的许多缺点，并允许对NAFLD进行全面和客观的评估。MRI能够在一次检查中提供关于肝脏脂肪、铁和纤维化的无混淆生物标志物——虚拟活检已成为临床现实。在本文中，我们将综述传统超声、CT和MR成像在NAFLD诊断中的效用和局限性。还将讨论NAFLD成像生物标志物的最新进展，重点是多参数定量MRI。
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