[人嗜T淋巴细胞病毒1型碱性亮氨酸拉链因子（HBZ）：在人嗜T淋巴细胞病毒1型致癌作用中的角色]

[HTLV-1 bZIP Factor (HBZ): Roles in HTLV-1 Oncogenesis].

作者信息

Wu Wencai, Cheng Wenzhao, Chen Mengyun, Xu Lingling, Zhao Tiejun

出版信息

Bing Du Xue Bao. 2016 Mar;32(2):235-42.

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus demonstrated to be associated with human disease. Infection by the HTLV-1 can cause T-cell leukemia (ATL) in adults. HTLV-1 bZIP factor (HBZ) is a viral protein encoded by the minus strand of the HTLV-1 provirus. Among the regulatory and accessory genes of HTLV-1, HBZ is the only gene that remains intact and which is expressed consistently in all patients with ATL. Moreover, HBZ has a critical role in the leukemogenesis of ATL. Here, we review the function of HBZ in the oncogenesis of HTLV-1 and its molecular mechanism of action.

摘要

人类嗜T淋巴细胞病毒1型（HTLV-1）是一种已被证明与人类疾病相关的逆转录病毒。HTLV-1感染可导致成人T细胞白血病（ATL）。HTLV-1 bZIP因子（HBZ）是由HTLV-1前病毒负链编码的一种病毒蛋白。在HTLV-1的调节基因和辅助基因中，HBZ是唯一保持完整且在所有ATL患者中持续表达的基因。此外，HBZ在ATL的白血病发生过程中起关键作用。在此，我们综述HBZ在HTLV-1肿瘤发生中的功能及其分子作用机制。