Zorena Katarzyna, Jachimowicz-Duda Olga, Wąż Piotr
a Department of Immunobiology and Environment Microbiology , Medical University of Gdańsk , Gdańsk , Poland .
b Diabetic Outpatient Clinic in Gdynia , Gdynia , Poland , and.
Biomarkers. 2016;21(3):276-82. doi: 10.3109/1354750X.2016.1138321. Epub 2016 Feb 5.
In the present study, we have decided to evaluate whether serum interleukin 34 (IL-34) levels may have diagnostic value in predicting the risk of vascular diabetic complications. The study included 49 patients with type 2 diabetes mellitus (T2DM) and 23 high-risk group. The receiver operating characteristic (ROC) curve analysis has shown that IL-34 has more discriminatory power than C-reactive protein (CRP) for the risk of diabetic complications. The cut-off value for IL-34 was established as 91.2 pg/mL. The gist of our research was identification of IL-34 as an additional potential inflammatory biomarker for the prediction of the risk of vascular diabetic complications.
在本研究中，我们决定评估血清白细胞介素34（IL-34）水平在预测血管性糖尿病并发症风险方面是否具有诊断价值。该研究纳入了49例2型糖尿病（T2DM）患者和23例高危人群。受试者工作特征（ROC）曲线分析表明，对于糖尿病并发症风险，IL-34比C反应蛋白（CRP）具有更强的鉴别能力。IL-34的临界值确定为91.2 pg/mL。我们研究的要点是将IL-34鉴定为预测血管性糖尿病并发症风险的另一种潜在炎症生物标志物。
