Fischer Sarah C L, Levy Oren, Kroner Elmar, Hensel René, Karp Jeffrey M, Arzt Eduard
INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany; Department of Materials Science and Engineering, Saarland University, Campus D2 2, 66123 Saarbrücken, Germany; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Biomedical Engineering, Department of Medicine, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA 02139, USA.
Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Biomedical Engineering, Department of Medicine, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA 02139, USA.
J Mech Behav Biomed Mater. 2016 Aug;61:87-95. doi: 10.1016/j.jmbbm.2016.01.014. Epub 2016 Jan 25.
Patterned microstructures represent a potential approach for improving current wound closure strategies. Microstructures can be fabricated by multiple techniques including replica molding of soft polymer-based materials. However, polymeric microstructures often lack the required shear resistance with tissue needed for wound closure. In this work, scalable microstructures made from composites based on polydimethylsiloxane (PDMS) were explored to enhance the shear resistance with wet tissue. To achieve suitable mechanical properties, PDMS was reinforced by incorporation of polyethylene (PE) particles into the pre-polymer and by coating PE particle reinforced substrates with parylene. The reinforced microstructures showed a 6-fold enhancement, the coated structures even a 13-fold enhancement in Young׳s modulus over pure PDMS. Shear tests of mushroom-shaped microstructures (diameter 450µm, length 1mm) against chicken muscle tissue demonstrate first correlations that will be useful for future design of wound closure or stabilization implants.
图案化微结构是改进当前伤口闭合策略的一种潜在方法。微结构可以通过多种技术制造，包括基于软聚合物材料的复制成型。然而，聚合物微结构通常缺乏伤口闭合所需的与组织的抗剪切性。在这项工作中，探索了由聚二甲基硅氧烷（PDMS）基复合材料制成的可扩展微结构，以增强与湿组织的抗剪切性。为了获得合适的机械性能，通过将聚乙烯（PE）颗粒掺入预聚物中以及用聚对二甲苯涂覆PE颗粒增强的基材来增强PDMS。与纯PDMS相比，增强后的微结构的杨氏模量提高了6倍，涂覆结构甚至提高了13倍。针对鸡肌肉组织的蘑菇形微结构（直径450μm，长度1mm）的剪切试验证明了初步的相关性，这将有助于未来伤口闭合或稳定植入物的设计。
