Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Key Laboratory of Disease Proteomics of Chongqing, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu, China.
Colloids Surf B Biointerfaces. 2018 Jun 1;166:61-71. doi: 10.1016/j.colsurfb.2018.03.008. Epub 2018 Mar 12.
Toward fabricating a novel multifunctional wound dressing material, we incorporated a series of contents of reduced graphene oxide (rGO) sheets into polydimethylsiloxane (PDMS) matrix to prepare the rGO-PDMS composite membrane and be used for wound dressing. The pore structure, dispersion of rGO, physical properties, water vapor transmission rate (WVTR), cytotoxicity and antibacterial activity were studied. Finally, the effect of the rGO-PDMS composite membrane on wound healing was investigated on a murine full-thickness skin wound model. The rGO-PDMS composite membrane exhibited bionic performance (ordered pore structure and suitable WVTR), improved mechanical properties, good compatibility and effective antibacterial activity. In vivo experiment indicated that the rGO-PDMS composite membrane could accelerate wound healing via enhancement of the re-epithelialization and granulation tissue formation. These findings suggest that rGO doping PDMS uniquely resulted in a multifunctional material for potential use in wound dressing.
为了制备新型多功能伤口敷料材料，我们将一系列还原氧化石墨烯 (rGO) 片掺入聚二甲基硅氧烷 (PDMS) 基质中，以制备 rGO-PDMS 复合膜并用于伤口敷料。研究了孔结构、rGO 的分散、物理性能、水蒸气透过率 (WVTR)、细胞毒性和抗菌活性。最后，在小鼠全层皮肤伤口模型上研究了 rGO-PDMS 复合膜对伤口愈合的影响。rGO-PDMS 复合膜表现出仿生性能（有序的孔结构和合适的 WVTR）、改善的机械性能、良好的相容性和有效的抗菌活性。体内实验表明，rGO-PDMS 复合膜可通过促进再上皮化和肉芽组织形成来加速伤口愈合。这些发现表明，rGO 掺杂 PDMS 独特地产生了一种多功能材料，可潜在用于伤口敷料。
