压缩染色质以确保肌肉卫星细胞静止
Compacting Chromatin to Ensure Muscle Satellite Cell Quiescence.
机构信息
Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
出版信息
Cell Stem Cell. 2016 Feb 4;18(2):162-4. doi: 10.1016/j.stem.2016.01.009.
Satellite cells comprise a pool of quiescent stem cells that repair muscle damage, but the mechanisms enforcing their quiescence are poorly defined. In this issue of Cell Stem Cell, Boonsanay et al. (2016) show that the histone methyltransferase Suv4-20H1 maintains satellite cell quiescence by promoting a heterochromatic state through transcriptional repression of the myogenic master regulator MyoD.
卫星细胞是一种静止的干细胞，可以修复肌肉损伤，但维持其静止状态的机制尚未完全确定。在本期《细胞-干细胞》杂志上，Boonsanay 等人（2016）表明，组蛋白甲基转移酶 Suv4-20H1 通过抑制肌生成主调控因子 MyoD 的转录，促进卫星细胞的异染色质状态，从而维持卫星细胞的静止状态。
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