Lan Fengling, Lyu Jun, Guo Yu, Bian Zheng, Yu Canqing, Zhou Huiyan, Tan Yunlong, Pei Pei, Cao Weihua, Chen Junshi, Chen Zhengming, Li Liming
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Chinese Academy of Medical Sciences.
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Nov;36(11):1205-9.
To describe the area specific differences in lung function indices and prevalence of airflow obstruction (AFO) in adults found by China Kadoorie Biobank (CKB) study, involving 512 495 adults, in 10 areas in China.
The detailed information on lung function indices (FEV, and FVC) and prevalence of AFO (diagnosed according to GOLD and LLN criteria) of subjects aged 30-79 years were analyzed, those with abnormal lung function indices at baseline survey were excluded.
The FEV1 and FVC among males (2.66 L, 3.16 L) were higher than those among females (1.99 L, 2.35 L). The FEV1 and FVC were highest in Henan and Harbin. The prevalence of AFO diaonosed according to GOLD criteria was 5.13% in males, higher than that in females (3.75%). The prevalence of AFO was higher in rural area than in urban area (males: 6.32% vs. 3.47%; females: 4.26% vs. 2.97%). The prevalence of AFO was highest in Sichuan (13.34% in males, 10.70% in females), followed by that in Suzhou, Henan and Hunan. The prevalence of AFO diagnosed according to LLN criteria (6.93% in males, 6.29% in females) was higher than that diagnosed according to GOLD criteria, but the area specific difference was similar.
The lung function indices and the prevalence of AFO in adults varied greatly among the 10 areas covered by CKB study.
描述中国嘉道理生物样本库（CKB）研究在中国10个地区的512495名成年人中发现的肺功能指标的区域特异性差异以及气流受限（AFO）的患病率。
分析了30 - 79岁受试者的肺功能指标（第一秒用力呼气容积[FEV₁]和用力肺活量[FVC]）及AFO患病率（根据全球慢性阻塞性肺疾病倡议[GOLD]和下限值[LLN]标准诊断）的详细信息，排除了基线调查时肺功能指标异常的受试者。
男性的FEV₁和FVC（分别为2.66L、3.16L）高于女性（分别为1.99L、2.35L）。FEV₁和FVC在河南和哈尔滨最高。根据GOLD标准诊断的AFO患病率男性为5.13%，高于女性（3.75%）。农村地区AFO的患病率高于城市地区（男性：6.32%对3.47%；女性：4.26%对2.97%）。AFO患病率在四川最高（男性为13.34%，女性为10.70%），其次是苏州、河南和湖南。根据LLN标准诊断的AFO患病率（男性为6.93%，女性为6.29%）高于根据GOLD标准诊断的患病率，但区域特异性差异相似。
在CKB研究覆盖的10个地区中，成年人的肺功能指标和AFO患病率差异很大。
