Persky Susan, Ferrer Rebecca A, Klein William M P
Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, 31 Center Drive, B1B36, Bethesda, MD, 20892, USA.
Basic Biobehavioral and Psychological Sciences Branch, Behavioral Research Program, National Cancer Institute, Rockville, MD, USA.
Ann Behav Med. 2016 Jun;50(3):452-9. doi: 10.1007/s12160-016-9771-2.
As evidence mounts regarding associations between genetics and body weight, it is essential to understand how to communicate this information, and factors like emotion that could moderate the effectiveness of messages.
We assessed influences of emotion on reactions to weight-related genomic information in a virtual clinical setting.
An online representative US sample of overweight women was randomized to receive an emotion induction (anger, fear, or neutral) paired with information about genomic or behavioral influences on weight in an interaction with a virtual doctor.
Receiving genomic information led to reduced attributions of lifestyle causes for weight and behavioral intentions, but only among individuals in a fear state.
The current study is among the first to reinforce the concern that discussing genomic underpinnings of overweight could undercut health behavior, and highlights the importance of identifying factors like emotion that influence interpretation of genomic information. Clinicaltrials.gov NCT01888913.
随着关于基因与体重之间关联的证据不断增加，了解如何传达这些信息以及诸如情绪等可能影响信息效果的因素至关重要。
我们在虚拟临床环境中评估了情绪对体重相关基因组信息反应的影响。
将美国超重女性的在线代表性样本随机分组，使其在与虚拟医生互动时接受情绪诱导（愤怒、恐惧或中性），并伴有关于基因或行为对体重影响的信息。
接受基因组信息导致对体重的生活方式成因的归因减少以及行为意图降低，但仅在处于恐惧状态的个体中如此。
本研究是最早强化如下担忧的研究之一，即讨论超重的基因基础可能会削弱健康行为，并强调识别诸如情绪等影响基因组信息解读的因素的重要性。Clinicaltrials.gov NCT01888913。
