Singh Bhupendra Pal, Dwivedi Shailendra, Dhakad Urmila, Murthy Ramesh Chandra, Choubey Vimal Kumar, Goel Apul, Sankhwar Satya Narayan
Department of Urology, King George's Medical University, Lucknow, 226003 U.P. India.
Analytic Chemistry Section, CSIR - Indian Institute of Toxicology Research, Lucknow, 226016 U.P. India.
Indian J Clin Biochem. 2016 Mar;31(1):50-6. doi: 10.1007/s12291-015-0497-x. Epub 2015 Apr 16.
Deficiency or excess of certain trace elements has been considered as risk factor for prostate cancer. This study was aimed to detect differential changes and mutual correlations of selected trace elements in prostate cancer tissue versus benign prostatic hyperplasia tissue. Zinc, copper, iron, calcium and selenium were analysed in histologically proven 15 prostate cancer tissues and 15 benign prostatic hyperplasia tissues using atomic absorption spectrophotometer. Unpaired two tailed t test/Mann-Whitney U test and Pearson correlation coefficient were used to compare the level of trace elements, elemental ratios and their interrelations. As compared to benign prostatic tissue, malignant prostatic tissue had significantly lower selenium (p = 0.038) and zinc (p = 0.043) concentrations, a lower zinc/iron ratio (p = 0.04) and positive correlation of selenium with zinc (r = 0.71, p = 0.02) and iron (r = 0.76, p = 0.009). Considerably divergent interrelationship of elements and elemental ratios in prostate cancer versus benign prostatic hyperplasia was noted. Understanding of differential elemental changes and their interdependence may be useful in defining the complex metabolic alterations in prostate carcinogenesis with potential for development of element based newer diagnostic, preventive and therapeutic strategies. Further studies may be needed to elucidate this complex relationship between trace elements and prostate carcinogenesis.
某些微量元素的缺乏或过量被认为是前列腺癌的危险因素。本研究旨在检测前列腺癌组织与良性前列腺增生组织中所选微量元素的差异变化及相互关系。使用原子吸收分光光度计对15例经组织学证实的前列腺癌组织和15例良性前列腺增生组织中的锌、铜、铁、钙和硒进行分析。采用非配对双尾t检验/曼-惠特尼U检验和皮尔逊相关系数来比较微量元素水平、元素比率及其相互关系。与良性前列腺组织相比，恶性前列腺组织的硒（p = 0.038）和锌（p = 0.043）浓度显著降低，锌/铁比率较低（p = 0.04），且硒与锌（r = 0.71，p = 0.02）和铁（r = 0.76，p = 0.009）呈正相关。注意到前列腺癌与良性前列腺增生中元素及元素比率的相互关系存在显著差异。了解元素的差异变化及其相互依赖性可能有助于确定前列腺癌发生过程中复杂的代谢改变，为基于元素的新型诊断、预防和治疗策略的开发提供可能。可能需要进一步的研究来阐明微量元素与前列腺癌发生之间的这种复杂关系。
