前列腺癌患者血清微量元素水平
Serum levels of trace elements in patients with prostate cancer.
作者信息
Kaba Mehmet, Pirincci Necip, Yuksel Mehmet Bilgehan, Gecit Ilhan, Gunes Mustafa, Ozveren Huseyin, Eren Huseyin, Demir Halit
机构信息
Department of Urology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey E-mail :
出版信息
Asian Pac J Cancer Prev. 2014;15(6):2625-9. doi: 10.7314/apjcp.2014.15.6.2625.
BACKGROUND
Trace elements are major components of biological structures; however, excessive levels of these elements can be toxic.
MATERIALS AND METHODS
In the present study, serum levels of trace elements were measured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnace atomic absorption spectrophotometry.
RESULTS
It was found that there was an increase in serum levels of Co, Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostate cancer (p<0.05).
CONCLUSIONS
These changes may be important in the pathogenesis of prostate cancers; however, further prospective studies are needed to identify relationships between prostate cancer and trace elements.
背景
微量元素是生物结构的主要组成部分；然而，这些元素水平过高可能具有毒性。
材料与方法
在本研究中，采用石墨炉原子吸收分光光度法测定了30例新诊断为前列腺癌的患者和32名健康志愿者的血清微量元素水平。
结果
发现前列腺癌患者血清中钴、铜、镁和铅水平升高（p<0.05），而铁、锰和锌水平降低（p<0.05）。
结论
这些变化可能在前列腺癌的发病机制中具有重要意义；然而，需要进一步的前瞻性研究来确定前列腺癌与微量元素之间的关系。
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