Barski Dimitri, Gerullis Holger, Ecke Thorsten, Varga Gabriella, Boros Mihaly, Pintelon Isabel, Timmermans Jean-Pierre, Winter Alexander, Bagner Jens-Willem, Otto Thomas
Department of Urology, Lukas Hospital Neuss, Germany.
Department of Urology, HELIOS Hospital, Bad Saarow, Germany.
Cent European J Urol. 2015;68(4):459-61. doi: 10.5173/ceju.2015.683. Epub 2015 Nov 13.
Complex vesico-vaginal fistula (VVF) has a high recurrence rate and so the repair with graft tissues seems to be favorable. Amniotic membrane (AM) plays an increasing role as a scaffold for the repair of defect tissue due to its unique biological properties with regard to promoting wound healing.
An innovative surgical procedure for AM-assisted repair of a complex vesico-vaginal fistula as the Idea Stage following the IDEAL recommendations is presented. The development of amnion preparation and the involved surgical steps are described.
We are able to report a successful repair of VVF by abdominal approach with an amniotic membrane graft. Good functional results, no adverse events and no graft rejection have been detected.
Favorable results confirm the technical simplicity, safety and efficacy of this procedure. Following the IDEAL recommendations, consecutive animal experiments and a cohort study are in progress.
复杂性膀胱阴道瘘（VVF）的复发率很高，因此使用移植组织进行修复似乎是有利的。羊膜（AM）因其在促进伤口愈合方面的独特生物学特性，作为修复缺损组织的支架发挥着越来越重要的作用。
介绍了一种按照IDEAL建议处于概念阶段的创新性手术方法，即采用羊膜辅助修复复杂性膀胱阴道瘘。描述了羊膜制备的过程及相关手术步骤。
我们报告了通过腹部入路使用羊膜移植成功修复膀胱阴道瘘。未检测到不良事件和移植排斥反应，功能恢复良好。
良好的结果证实了该手术方法技术简单、安全且有效。按照IDEAL建议，后续将进行连续的动物实验和队列研究。
