Fishman I J, Flores F N, Scott F B, Spjut H J, Morrow B
Roy and Lillie Cullen Department of Urological Research, Baylor College of Medicine, Houston, Texas.
J Urol. 1987 Nov;138(5):1291-4. doi: 10.1016/s0022-5347(17)43586-5.
Several biodegradable and artificial materials have been used in the urinary tract for partial or total replacement of the bladder. Most of the graft materials have resulted in stone formation, collapse, rejection, or extrusion of the graft without adequate reconstruction of a functional bladder. In this paper, we present our assessment of the use of placental membranes as a feasible, economic, and acceptable organic agent for bladder reconstruction. Eight mongrel dogs were subjected to supratrigonal cystectomy, and then a 10 X 10 centimeter patch of human placental membrane was sutured to the remaining trigone in a watertight fashion. The dogs were sacrificed twelve weeks after surgery. Histologic examinations revealed evidence of regeneration of normal-appearing smooth muscle along the path of a retracting placental patch, and thus of reconstitution of a normal-appearing and functioning bladder. On the basis of this study, we believe that placental membranes, because of their low antigenic properties and easy availability, provide an excellent graft material for the urinary tract. Further studies concerning the application of this graft material in various pathological conditions are now in progress.
几种可生物降解材料和人工材料已被用于泌尿道，以部分或全部替代膀胱。大多数移植材料都导致了结石形成、塌陷、排斥反应或移植材料的挤出，而没有对功能性膀胱进行充分重建。在本文中，我们展示了我们对使用胎盘膜作为一种可行、经济且可接受的有机制剂进行膀胱重建的评估。八只杂种狗接受了膀胱三角区上方的膀胱切除术，然后将一块10×10厘米的人胎盘膜以防水方式缝合到剩余的膀胱三角区。术后十二周处死这些狗。组织学检查显示，沿着回缩的胎盘补片路径有正常外观平滑肌再生的迹象，因此有正常外观且功能正常的膀胱重建的迹象。基于这项研究，我们认为胎盘膜因其低抗原性和易于获取，为泌尿道提供了一种极好的移植材料。目前正在进行关于这种移植材料在各种病理状况下应用的进一步研究。
