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1948年至1995年美国沙门氏菌的抗菌药物耐药性

Antimicrobial Resistance in Salmonella in the United States from 1948 to 1995.

作者信息

Tadesse Daniel A, Singh Aparna, Zhao Shaohua, Bartholomew Mary, Womack Niketta, Ayers Sherry, Fields Patricia I, McDermott Patrick F

机构信息

U.S. Food and Drug Administration, Center for Veterinary Medicine, U.S. Department of Health and Human Services, Laurel, Maryland, USA.

National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, USA.

出版信息

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2567-71. doi: 10.1128/AAC.02536-15. Print 2016 Apr.

Abstract

We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inSalmonella entericaserotype Typhimurium. An increase in multidrug resistance was observed for each decade since the 1950s. These data help show howSalmonellaevolved over the past 6 decades, after the introduction of new antimicrobial agents.

摘要

我们对2149株临床沙门氏菌菌株进行了一项回顾性研究,以帮助记录抗菌药物耐药性的历史出现情况。对包括氨苄青霉素、氯霉素、链霉素、磺胺甲恶唑和四环素在内的较老药物的耐药性显著增加,这些耐药性在肠炎沙门氏菌鼠伤寒血清型中最为常见。自20世纪50年代以来,每十年观察到多重耐药性都在增加。这些数据有助于显示自引入新的抗菌药物后,沙门氏菌在过去60年里是如何演变的。

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