安哥拉的恶性疟原虫耐药性
Plasmodium falciparum drug resistance in Angola.
作者信息
Fançony Cláudia, Brito Miguel, Gil Jose Pedro
机构信息
Health Research Center of Angola (CISA, translated), Caxito, Angola.
Lisbon School of Health Technology, Polytechnic Institute of Lisbon, Portugal, Lisbon, Portugal.
出版信息
Malar J. 2016 Feb 9;15:74. doi: 10.1186/s12936-016-1122-z.
Abstract
Facing chloroquine drug resistance, Angola promptly adopted artemisinin-based combination therapy as the first-line to treat malaria. Currently, the country aims to consolidate malaria control, while preparing for the elimination of the disease, along with others African countries in the region. However, the remarkable capacity of Plasmodium to develop drug resistance represents an alarming threat for those achievements. Herein, the available, but relatively scarce and dispersed, information on malaria drug resistance in Angola, is reviewed and discussed. The review aims to inform but also to encourage future research studies that monitor and update the information on anti-malarial drug efficacy and prevalence of molecular markers of drug resistance, key fields in the context and objectives of elimination.
摘要
面对氯喹耐药性问题，安哥拉迅速采用以青蒿素为基础的联合疗法作为治疗疟疾的一线疗法。目前，该国旨在巩固疟疾防治成果，同时与该地区其他非洲国家一道为消除该疾病做准备。然而，疟原虫产生耐药性的显著能力对这些成果构成了令人担忧的威胁。在此，对安哥拉现有的、但相对稀少且分散的疟疾耐药性信息进行了综述和讨论。该综述旨在提供信息，同时鼓励未来开展研究，监测并更新有关抗疟药物疗效和耐药性分子标记物流行情况的信息，这些是消除疟疾背景和目标下的关键领域。
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