Okazaki Tadaharu, Asahara Takashi, Yamataka Atsuyuki, Ogasawara Yuki, Lane Geoffrey J, Nomoto Koji, Nagata Satoru, Yamashiro Yuichiro
*Department of Pediatric Surgery, Juntendo University Urayasu Hospital, Chiba, Japan†Department of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine‡Yakult Central Institute, Yakult Honsha Co, Ltd., Tokyo, Japan§Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan||Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan.
J Pediatr Gastroenterol Nutr. 2016 Jul;63(1):46-50. doi: 10.1097/MPG.0000000000001140.
The efficacy of perioperative probiotic administration has been reported in adults. We examined the effects of orally administered Bifidobacterium breve strain Yakult (BBG-01) on outcomes in pediatric surgical cases by assessing intestinal and blood microbiota. BBG-01 was well tolerated without adverse effects, and postoperative infectious complications were significantly decreased. Fecal analysis showed increased Bifidobacterium and decreased Enterobacteriaceae, Clostridium difficile, and Pseudomonas. Concentrations of fecal acetic acid were significantly increased, maintaining fecal pH at <7.0. The incidence of detecting bacteria in blood was significantly reduced. BBG-01 improved the intestinal environment, and may be implicated in suppressing bacterial translocation.
围手术期给予益生菌在成人中的疗效已有报道。我们通过评估肠道和血液微生物群，研究了口服养乐多短双歧杆菌菌株（BBG-01）对小儿外科病例结局的影响。BBG-01耐受性良好，无不良反应，术后感染性并发症显著减少。粪便分析显示双歧杆菌增加，肠杆菌科、艰难梭菌和假单胞菌减少。粪便乙酸浓度显著增加，使粪便pH值维持在<7.0。血液中检测到细菌的发生率显著降低。BBG-01改善了肠道环境，可能与抑制细菌易位有关。
