Department of Pediatric Surgery, Juntendo University Urayasu Hospital, Tokyo, Japan.
Ann Nutr Metab. 2017;71 Suppl 1:31-36. doi: 10.1159/000479921. Epub 2017 Sep 28.
Major surgical procedures can alter intestinal microbiota and disrupt the intestinal barrier function, leaving the patient at risk for infection. Probiotics are defined as live microorganisms that confer a health benefit on the host when administered in adequate amounts. Although the efficacy of administering probiotics perioperatively to adults has been reported, the clinical significance of probiotics in children undergoing surgery is still unclear. This study provides a brief overview of our randomized controlled trial of preoperative probiotic administration to children, and discusses the relationship between probiotics and their effects in the perioperative period, particularly focusing on bacteremia.
重大手术操作可改变肠道微生物群，并破坏肠道屏障功能，使患者面临感染风险。益生菌被定义为当以足够量给予时赋予宿主健康益处的活微生物。虽然已经报道了围手术期给予成人益生菌的疗效，但益生菌在接受手术的儿童中的临床意义仍不清楚。本研究简要概述了我们对儿童进行术前益生菌给药的随机对照试验，并讨论了益生菌及其在围手术期的作用之间的关系，特别是关注菌血症。
