Nguyen Nhung T, Raskopf Esther, Shah-Hosseini Kija, Zadoyan Gregor, Mösges Ralph
Institute of Medical Statistics, Informatics & Epidemiology (IMSIE), Faculty of Medicine, University of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany.
Immunotherapy. 2016;8(3):331-49. doi: 10.2217/imt.15.121. Epub 2016 Feb 9.
To modify the course of allergy, different types of specific allergen immunotherapy have been developed such as sublingual immunotherapy and subcutaneous immunotherapy with native allergens or subcutaneous immunotherapy with polymerized allergoids. However, the optimal specific immunotherapy, especially for cat allergy, remains undetermined. Few studies investigating immunotherapy in cat allergy have been published, and the risk of serious adverse reactions and systemic reactions has often been an important issue. Monomeric allergoids have lower allergenic potential while their immunogenicity remains constant, resulting in excellent safety with notable efficacy. Specific immunotherapy with monomeric allergoids could, therefore, be of high value, especially in cat allergy as well as other types of allergy, and bring relief to a great community of patients.
为改变过敏病程，已研发出不同类型的特异性变应原免疫疗法，如舌下免疫疗法、使用天然变应原的皮下免疫疗法或使用聚合类变应原的皮下免疫疗法。然而，最佳的特异性免疫疗法，尤其是针对猫过敏的疗法，仍未确定。很少有关于猫过敏免疫疗法的研究发表，严重不良反应和全身反应的风险一直是一个重要问题。单体类变应原的变应原性较低，而其免疫原性保持不变，因此安全性极佳且疗效显著。因此，单体类变应原特异性免疫疗法可能具有很高的价值，尤其是在猫过敏以及其他类型的过敏中，可为广大患者带来缓解。
