Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Int J Mol Sci. 2024 Sep 29;25(19):10520. doi: 10.3390/ijms251910520.
Inhalation allergies caused by cats and dogs can lead to a range of discomforting symptoms, such as rhinitis and asthma, in humans. With the increasing popularity of and care provided to these companion animals, the allergens they produce pose a growing threat to susceptible patients' health. Allergens from cats and dogs have emerged as significant risk factors for triggering asthma and allergic rhinitis worldwide; however, there remains a lack of systematic measures aimed at assisting individuals in recognizing and preventing allergies caused by these animals. This review provides comprehensive insights into the classification of cat and dog allergens, along with their pathogenic mechanisms. This study also discusses implementation strategies for prevention and control measures, including physical methods, gene-editing technology, and immunological approaches, as well as potential strategies for enhancing allergen immunotherapy combined with immunoinformatics. Finally, it presents future prospects for the prevention and treatment of human allergies caused by cats and dogs. This review will improve knowledge regarding allergies to cats and dogs while providing insights into potential targets for the development of next-generation treatments.
人与猫和狗之间的吸入性过敏反应会导致一系列令人不适的症状，例如鼻炎和哮喘。随着这些伴侣动物越来越受欢迎且得到人们的悉心照料，它们产生的过敏原对易过敏患者的健康构成了越来越大的威胁。猫和狗过敏原已成为全球范围内引发哮喘和过敏性鼻炎的重要危险因素；然而，目前仍然缺乏系统的措施来帮助人们识别和预防这些动物引起的过敏。这篇综述全面介绍了猫和狗过敏原的分类及其致病机制。本文还讨论了预防和控制措施的实施策略，包括物理方法、基因编辑技术和免疫方法，以及结合免疫信息学增强过敏原免疫疗法的潜在策略。最后，本文对预防和治疗人类猫和狗过敏进行了展望。本综述将提高人们对猫和狗过敏的认识，并为开发下一代治疗方法提供潜在的目标。
