Yamada T, Kawakami S, Yoshida Y, Kawamura H, Ohta S, Abe K, Hamada H, Dohi S, Ichizuka K, Takita H, Baba Y, Matsubara S, Mochizuki J, Unno N, Maegawa Y, Maeda M, Inubashiri E, Akutagawa N, Kubo T, Shirota T, Oda Y, Yamada T, Yamagishi E, Nakai A, Fuchi N, Masuzaki H, Urabe S, Kudo Y, Nomizo M, Sagawa N, Maeda T, Kamitomo M, Kawabata K, Kataoka S, Shiozaki A, Saito S, Sekizawa A, Minakami H
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Department of Obstetrics and Gynecology, Fukuda Hospital, Kumamoto, 860-0004, Japan.
Eur J Clin Microbiol Infect Dis. 2016 Apr;35(4):665-71. doi: 10.1007/s10096-016-2585-0. Epub 2016 Feb 10.
This study was performed to determine whether multiparous pregnant women are prone to influenza. A questionnaire survey was conducted at 19 centres located throughout Japan, targeting all 6,694 postpartum women within 7 days after birth before leaving the hospital. All women gave birth during the study period between March 1, 2015, and July 31, 2015. Data regarding vaccination and influenza infection in or after October 2014, age, previous experience of childbirth, and number and ages of cohabitants were collected. Seventy-eight percent (n = 51,97) of women given questionnaires responded. Of these, 2,661 (51 %) and 364 (7.0 %) women reported having been vaccinated and having contracted influenza respectively. Multiparous women had a higher risk of influenza regardless of vaccination status (8.9 % [121/1362] vs 5.7 % [74/1299], relative risk [95 % confidence interval], 1.80 [1.36 to 2.38] for vaccinated and 9.3 % [112/1198] vs 4.3 % [57/1328], 2.18 [1.60 to 2.97] for unvaccinated women) compared to primiparous women. The risk of influenza increased with increasing number of cohabitants: 4.8 % (100/2089), 7.5 %, (121/1618), 9.0 %, (71/785), and 10.4 % (58/557) for women with 1, 2, 3, and ≥4 cohabitants respectively. Family size is a risk factor for influenza infection in pregnancy.
本研究旨在确定经产妇是否易患流感。在日本各地的19个中心进行了问卷调查，对象为所有在2015年3月1日至2015年7月31日研究期间分娩、产后7天内尚未出院的6694名产妇。收集了2014年10月及以后的疫苗接种和流感感染数据、年龄、既往分娩经历以及同居者数量和年龄。78%（n = 5197）的受访女性回复了问卷。其中，分别有2661名（51%）和364名（7.0%）女性报告接种过疫苗和感染过流感。无论疫苗接种状况如何，经产妇患流感的风险均高于初产妇（接种疫苗者中，8.9%[121/1362]对5.7%[74/1299]，相对风险[95%置信区间]为1.80[1.36至2.38]；未接种疫苗者中，9.3%[112/1198]对4.3%[57/1328]，2.18[1.60至2.97]）。流感风险随同居者数量增加而升高：同居者数量为1、2、3和≥4人的女性，患流感的比例分别为4.8%（100/2089）、7.5%（121/1618）、9.0%（71/785）和10.4%（58/557）。家庭规模是孕期流感感染的一个风险因素。
