Bagheripuor Fatemeh, Gharibzadeh Safoora, Ghanbari Mahboubeh, Amouzegar Atieh, Tohidi Maryam, Azizi Fereidoun, Ghasemi Asghar
a Endocrine Physiology Research Center , Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
b Endocrine Research Center , Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Endocr Res. 2016 Aug;41(3):193-9. doi: 10.3109/07435800.2015.1126844. Epub 2016 Feb 11.
Nitric oxide participates in the regulation of thyroid function.
The purpose of this study was to determine whether there is an association between serum nitric oxide metabolites (NOx) and free thyroxine (free T4), anti-thyroid peroxidase (anti-TPO), and thyroid-stimulating hormone (TSH) levels.
Study subjects were adults, aged ≥20 years, who participated in the Tehran Thyroid Study (TTS). In a cross-sectional study, in the third phase of TTS, serum NOx concentrations were measured in 1974 adult participants; pregnant women and subjects who had chronic diarrhea, cancer, weight loss, and hospitalization within the past 3 months were excluded, as were those taking medicines that affect thyroid function; the remaining 1771 subjects were grouped according to tertiles of free T4, anti-TPO, and TSH. Spearman's correlation coefficients and multivariable linear regression analysis were used to determine the relationship between serum NOx levels and free T4, anti-TPO, and TSH.
Serum NOx levels were negatively correlated with free T4 in men (r = -0.083; p = 0.029). An inverse association between the third tertile of free T4 and NOx levels was found in both non-adjusted (β = -0.095, p = 0.031) and multivariable-adjusted (β = -0.094, p = 0.039) analyses, only in men. After multivariable adjustment, the third tertile of anti-TPO was significantly associated with NOx levels in women (β = -0.067, p = 0.050).
Based on the result, serum NOx concentration was found to be associated with free T4 in men and anti-TPO in women.
一氧化氮参与甲状腺功能的调节。
本研究旨在确定血清一氧化氮代谢产物（NOx）与游离甲状腺素（游离T4）、抗甲状腺过氧化物酶（抗TPO）及促甲状腺激素（TSH）水平之间是否存在关联。
研究对象为年龄≥20岁的成年人，他们参与了德黑兰甲状腺研究（TTS）。在一项横断面研究中，于TTS的第三阶段，对1974名成年参与者测定了血清NOx浓度；排除了孕妇以及过去3个月内患有慢性腹泻、癌症、体重减轻和住院的受试者，以及正在服用影响甲状腺功能药物的受试者；其余1771名受试者根据游离T4、抗TPO和TSH的三分位数进行分组。采用Spearman相关系数和多变量线性回归分析来确定血清NOx水平与游离T4、抗TPO和TSH之间的关系。
男性血清NOx水平与游离T4呈负相关（r = -0.083；p = 0.029）。仅在男性中，未调整分析（β = -0.095，p = 0.031）和多变量调整分析（β = -0.094，p = 0.039）均发现游离T4的第三个三分位数与NOx水平呈负相关。多变量调整后，抗TPO的第三个三分位数与女性的NOx水平显著相关（β = -0.067，p = 0.050）。
基于结果发现，血清NOx浓度在男性中与游离T4相关，在女性中与抗TPO相关。
