Bahadoran Zahra, Mirmiran Parvin, Jeddi Sajad, Momenan Amir Abbas, Azizi Fereidoun, Ghasemi Asghar
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Diet Therapy, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Endocrinol Metab. 2018 Oct 14;16(4 Suppl):e84775. doi: 10.5812/ijem.84775. eCollection 2018 Oct.
We describe here the contributions of the Tehran lipid and glucose study (TLGS) to understanding different aspects of the nitrate (NO)-nitrite (NO)-nitric oxide (NO) pathway in health and disease.
All English-language documents from the TLGS, focused on NO pathway were searched using the PubMed, Scopus, and Embase databases.
Reference values of serum concentrations of NO metabolites (nitrate+nitrite or NOx) were 11.5 - 76.4, 10.1 - 65.6, and 10.3 - 66.8 μmol/L in men, women, and the total population, respectively. Circulating NOx was affected by age, smoking habits, menopause status, thyroid hormones, and various pathologic conditions. Elevated serum NOx was related to increased incidence of metabolic syndrome (odds ratio (OR) = 1.75, 95% confidence interval (CI) = 1.19 - 2.59), hypertriglyceridemic-waist phenotype (OR = 1.39, 95% CI = 1.05 - 1.93), chronic kidney disease (OR = 1.86, 95% CI = 1.10 - 3.14) in women, and cardiovascular disease (hazard ratio (HR) = 1.35, 95% CI = 1.01 - 1.80] in the total population. In participants with low vitamin C intake, higher intakes of NO (≥ 8.77 mg/d) were accompanied with increased risk of diabetes (HR = 2.43, 95% CI = 1.45 - 4.05). A decreased risk of hypertension (OR = 0.58, 95% CI = 0.33 - 0.98) and chronic kidney disease (OR = 0.50, 95% CI = 0.24 - 0.89) was observed in response to higher intakes of NO.
Circulating NOx is associated with and could predict the risk of metabolic disorders in a general population. Moreover, dietary NO/NO exposure from usual diets seems to contribute to development of noncommunicable diseases.
我们在此描述德黑兰脂质与血糖研究（TLGS）对理解健康与疾病中硝酸盐（NO）-亚硝酸盐（NO₂）-一氧化氮（NO）通路不同方面的贡献。
使用PubMed、Scopus和Embase数据库搜索了TLGS中所有聚焦于NO通路的英文文献。
男性、女性和总人口中血清NO代谢物（硝酸盐 + 亚硝酸盐或NOₓ）浓度的参考值分别为11.5 - 76.4、10.1 - 65.6和10.3 - 66.8 μmol/L。循环中的NOₓ受年龄、吸烟习惯、绝经状态、甲状腺激素和各种病理状况影响。血清NOₓ升高与代谢综合征发病率增加（优势比（OR）= 1.75，95%置信区间（CI）= 1.19 - 2.59）、高甘油三酯血症腰围表型（OR = 1.39，95% CI = 1.05 - 1.93）、女性慢性肾病（OR = 1.86，95% CI = 1.10 - 3.14）以及总人口中的心血管疾病（风险比（HR）= 1.35，95% CI = 1.01 - 1.80）相关。在维生素C摄入量低的参与者中，较高的NO摄入量（≥ 8.77 mg/d）与糖尿病风险增加相关（HR = 2.43，95% CI = 1.45 - 4.05）。较高的NO摄入量可降低高血压（OR = 0.58，95% CI = 0.33 - 0.98）和慢性肾病（OR = 0.50，95% CI = 0.24 - 0.89）的风险。
循环中的NOₓ与一般人群的代谢紊乱风险相关且可预测该风险。此外，日常饮食中的膳食NO/NO暴露似乎有助于非传染性疾病的发展。
