Hendricks Matthew R, Bomberger Jennifer M
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Virol. 2016 Apr 14;90(9):4258-4261. doi: 10.1128/JVI.01864-15. Print 2016 May.
Respiratory virus infections are common but generally self-limiting infections in healthy individuals. Although early clinical studies reported low detection rates, the development of molecular diagnostic techniques by PCR has led to an increased recognition that respiratory virus infections are associated with morbidity and acute exacerbations of chronic lung diseases, such as cystic fibrosis (CF). The airway epithelium is the first barrier encountered by respiratory viruses following inhalation and the primary site of respiratory viral replication. Here, we describe how the airway epithelial response to respiratory viral infections contributes to disease progression in patients with CF and other chronic lung diseases, including the role respiratory viral infections play in bacterial acquisition in the CF patient lung.
呼吸道病毒感染在健康个体中很常见，但通常为自限性感染。尽管早期临床研究报告的检出率较低，但聚合酶链反应（PCR）分子诊断技术的发展使人们越来越认识到，呼吸道病毒感染与慢性肺病（如囊性纤维化，CF）的发病率和急性加重有关。气道上皮是吸入后呼吸道病毒遇到的第一道屏障，也是呼吸道病毒复制的主要部位。在此，我们描述了气道上皮对呼吸道病毒感染的反应如何促进CF和其他慢性肺病患者的疾病进展，包括呼吸道病毒感染在CF患者肺部细菌感染中所起的作用。
