Flight William, Jones Andrew
a Oxford Adult Cystic Fibrosis Centre, Oxford University Hospitals NHS Foundation Trust , Oxford , UK.
b Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester NHS Foundation Trust , Manchester , UK.
Expert Rev Respir Med. 2017 Mar;11(3):221-227. doi: 10.1080/17476348.2017.1288102. Epub 2017 Feb 3.
Respiratory viruses, such as those that cause influenza and the common cold, are a regular feature of life for the entire human population. Among people with CF, these viruses are associated with prolonged respiratory illness and show a clear association with pulmonary exacerbations which in turn are associated with lung function decline and risk of death. Human rhinovirus is the most commonly encountered respiratory viral pathogen in CF although adenovirus, bocavirus, coronavirus, influenza, parainfluenza, metapneumovirus and respiratory syncytial virus are all also responsible for infections in this population. Areas covered: This article reviews the epidemiology, clinical impact and therapeutic options for respiratory virus infection in both children and adults with CF. Expert commentary: The management of CF to date has largely focused on airway clearance strategies, nutritional support and aggressive antibacterial therapy. We highlight the significant role that respiratory viruses play in CF lung disease and argue that these pathogens represent an under-exploited target in the battle to control patients' symptoms and disease progression.
呼吸道病毒，如那些引发流感和普通感冒的病毒，是全人类生活中的常见特征。在患有囊性纤维化（CF）的人群中，这些病毒与长期的呼吸道疾病相关，并且与肺部病情加重有着明显关联，而肺部病情加重又与肺功能下降和死亡风险相关。人鼻病毒是CF患者中最常遇到的呼吸道病毒病原体，不过腺病毒、博卡病毒、冠状病毒、流感病毒、副流感病毒、偏肺病毒和呼吸道合胞病毒也都会导致该人群感染。涵盖领域：本文综述了患有CF的儿童和成人呼吸道病毒感染的流行病学、临床影响及治疗选择。专家评论：迄今为止，CF的治疗主要集中在气道清理策略、营养支持和积极的抗菌治疗上。我们强调呼吸道病毒在CF肺部疾病中所起的重要作用，并认为这些病原体在控制患者症状和疾病进展的斗争中是一个未得到充分利用的靶点。
