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白内障超声乳化术后早期的角膜水肿:糖尿病患者与非糖尿病患者的定性比较病例对照研究

Corneal oedema after phacoemulsification in the early postoperative period: A qualitative comparative case-control study between diabetics and non-diabetics.

作者信息

Tsaousis Konstantinos T, Panagiotou Dimitrios Z, Kostopoulou Eirini, Vlatsios Vasileios, Stampouli Despoina

机构信息

Department of Ophthalmology, General Hospital of Xanthi, Greece; 2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Greece.

Department of Ophthalmology, General Hospital of Xanthi, Greece.

出版信息

Ann Med Surg (Lond). 2015 Dec 19;5:67-71. doi: 10.1016/j.amsu.2015.12.047. eCollection 2016 Feb.

Abstract

BACKGROUND

The occurrence and severity of corneal oedema after phacoemulsification is dependent on the integrity of corneal endothelial cells. The function of these cells is affected by diabetes mellitus and consequently the behaviour of the cornea in diabetic patients is of special interest.

AIM

To compare the frequency of corneal oedema in two age-matched groups of diabetics and non diabetic patients that underwent cataract surgery in the Ophthalmology Department of Xanthi General Hospital in Greece.

METHODS

A retrospective case control study was conducted in a retrospective fashion. Patients in the control and study groups were assessed regarding the severity of corneal oedema at three postoperative visits: days 1, 3-7, 10-14 after the operation. Ultrasound energy consumed during phacoemulsification was also a parameter of interest and possible correlations with the pre-existent cataract severity and the subsequent incidence of corneal oedema were investigated.

RESULTS

The difference in the incidence of severe corneal oedema between the study and control group was statistically significant: (4.5% non diabetics vs 14.3% diabetics). The consumed ultrasound energy did not define final clinical outcome.

CONCLUSIONS

The existence of diabetes mellitus type 2 appears to be a significant risk factor for the development of persistent corneal oedema. The results of our study led to the modification of the algorithm for postoperative follow-up of patients of this remote area of Greece.

摘要

背景

白内障超声乳化术后角膜水肿的发生及严重程度取决于角膜内皮细胞的完整性。这些细胞的功能受糖尿病影响,因此糖尿病患者角膜的表现备受关注。

目的

比较希腊克桑西综合医院眼科两组年龄匹配的糖尿病患者和非糖尿病患者白内障手术后角膜水肿的发生率。

方法

采用回顾性病例对照研究。在术后1天、3 - 7天、10 - 14天这三次随访时,对对照组和研究组患者的角膜水肿严重程度进行评估。超声乳化术中消耗的超声能量也是一个关注参数,并研究其与术前白内障严重程度及随后角膜水肿发生率的可能相关性。

结果

研究组和对照组严重角膜水肿发生率的差异具有统计学意义:(非糖尿病患者为4.5%,糖尿病患者为14.3%)。消耗的超声能量并不能决定最终的临床结果。

结论

2型糖尿病的存在似乎是持续性角膜水肿发生的一个重要危险因素。我们的研究结果导致了希腊这个偏远地区患者术后随访方案的修改。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ccf/4710706/71935d9eb4c8/gr1.jpg

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