Mac Aogáin M, Rogers T R, Crowley B
Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory, School of Medicine, Trinity College Dublin, Dublin, Ireland; Department of Microbiology, St James's Hospital, Dublin, Ireland.
New Microbes New Infect. 2015 Nov 27;9:58-62. doi: 10.1016/j.nmni.2015.11.012. eCollection 2016 Jan.
Whole-genome sequencing of 24 Proteus mirabilis isolates revealed the clonal expansion of two cefoxitin-resistant strains among patients with community-onset infection. These strains harboured bla CMY-2 within a chromosomally located integrative and conjugative element and exhibited multidrug resistance phenotypes. A predominant strain, identified in 18 patients, also harboured the PGI-1 genomic island and associated resistance genes, accounting for its broader antibiotic resistance profile. The identification of these novel multidrug-resistant strains among community-onset infections suggests that they are endemic to this region and represent emergent P. mirabilis lineages of clinical significance.
对24株奇异变形杆菌分离株进行全基因组测序，结果显示在社区获得性感染患者中，两种对头孢西丁耐药的菌株出现了克隆性扩增。这些菌株在一个位于染色体上的整合与接合元件中携带bla CMY-2基因，并表现出多重耐药表型。在18名患者中鉴定出的一株优势菌株还携带PGI-1基因组岛及相关耐药基因，这解释了其更广泛的抗生素耐药谱。在社区获得性感染中发现这些新型多重耐药菌株，表明它们在该地区呈地方性流行，代表了具有临床意义的新出现的奇异变形杆菌谱系。
