Beladi-Mousavi Seyed Seifollah, Jafarizade Mehrian, Shayanpour Shokouh, Bahadoram Mohammad, Moosavian Seyed Mostafa, Houshmand Gholamreza
Chronic Renal Failure Research Center, Department of Internal Medicine, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Chronic Renal Failure Research Center, Department of Internal Medicine, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, IR Iran; Medical Student Research Committee, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Nephrourol Mon. 2015 Nov 29;7(6):e31967. doi: 10.5812/numonthly.31967. eCollection 2015 Nov.
Restless legs syndrome (RLS) may be associated with increased morbidity and mortality among end-stage renal disease (ESRD) patients; however, it is a disorder that is neglected in dialysis centers.
The goal of this study was to investigate the clinical factors associated with RLS among ESRD patients.
This cross-sectional study was conducted on ESRD patients undergoing maintenance hemodialysis (HD) in three HD centers in Ahvaz city in Southwest Iran. Blood samples were obtained prior to a dialysis session to check the routine laboratory test results and assess the adequacy of dialysis. The presence of RLS was assessed by using the international RLS study group (IRLSSG) diagnostic criteria. The IRLSSG rating scale was also used to evaluate the severity of the RLS symptoms.
Of the 139 HD patients enrolled in this study, 60 were female (43.2%) and 79 were male (56.8%), with a mean age of 51.82 ± 13.31 years. The prevalence of RLS was 15.8% (22 patients), with 50% of them (11 patients) having severe or very severe symptoms. There was a significant relationship between RLS and longer durations of dialysis (P < 0.001). The mean level of serum ferritin was lower in patients without RLS, but it was not significant (P = 0.065). No significant differences were found according to age, gender, dialysis shifts, and hemoglobin (Hb) level among patients with and without RLS.
We conclude that a significant percentage of ESRD patients undergoing maintenance HD have severe or very severe RLS symptoms. The presence of RLS is associated to longer durations of dialysis.
不安腿综合征（RLS）可能与终末期肾病（ESRD）患者的发病率和死亡率增加有关；然而，这是一种在透析中心被忽视的疾病。
本研究的目的是调查ESRD患者中与RLS相关的临床因素。
这项横断面研究是在伊朗西南部阿瓦士市的三个血液透析（HD）中心对接受维持性血液透析的ESRD患者进行的。在透析 session 前采集血样以检查常规实验室检查结果并评估透析充分性。使用国际不安腿综合征研究组（IRLSSG）诊断标准评估RLS的存在。IRLSSG评分量表也用于评估RLS症状的严重程度。
本研究纳入的139例HD患者中，女性60例（43.2%），男性79例（56.8%），平均年龄51.82±13.31岁。RLS的患病率为15.8%（22例患者），其中50%（11例患者）有严重或非常严重的症状。RLS与透析时间较长之间存在显著关系（P<0.001）。无RLS患者的血清铁蛋白平均水平较低，但无统计学意义（P=0.065）。在有RLS和无RLS的患者中，根据年龄、性别、透析班次和血红蛋白（Hb）水平未发现显著差异。
我们得出结论，相当比例的接受维持性HD的ESRD患者有严重或非常严重的RLS症状。RLS的存在与透析时间较长有关。
