Guarderas Fernando, Leavell Yaowaree, Sengupta Trisha, Zhukova Mariya, Megraw Timothy L
Fernando Guarderas, MD, is an Emergency Medicine Resident, University of North Carolina, Chapel Hill, North Carolina. Yaowaree Leavell, MD, is an Internal Medicine Resident, Orlando Regional Medical Center, Internal Medicine Department, Orlando, Florida. Trisha Sengupta, BBA, is a Medical Student, Florida State University College of Medicine, Tallahassee, Florida. Mariya Zhukova, BS, is a Medical Student, Florida State University College of Medicine, Tallahassee, Florida. Timothy L. Megraw, PhD, is Associate Professor, Florida State University College of Medicine, Biomedical Sciences, Tallahassee, Florida.
Adv Skin Wound Care. 2016 Mar;29(3):131-4. doi: 10.1097/01.ASW.0000480359.58866.e9.
To examine the efficacy of the folk remedy of chicken-egg membrane dressing on wound healing.
Full-thickness excisional wounds were created on 14 male Sprague-Dawley rats in 2 separate trials. Each animal received 2 wounds on the upper back. One wound was untreated, and the other was dressed with chicken-egg membrane to assess its impact on wound healing. Half of the rats received egg membrane treatment on the inferior wound, whereas the other half received egg membrane treatment on the superior wound. Membrane replacement, wound debridement, and imaging were done on days 5, 8, and 10 and then imaging continued on days 12, 14, 16, 18, and 20 of the experiment. Healing rate was measured based on the wound area over the 20 days of the experiment.
The wounds dressed with chicken-egg membrane had a significantly (P < .01) faster rate of healing compared with the control at the early stages of healing between days 0 and 5. This group healed 21% faster during this early phase, compared with the control group. Overall, however, wound healing rates were indistinguishable from days 5 to 20.
Chicken-egg membrane dressing significantly improves healing of cutaneous wounds in the early stages of wound healing.
研究民间疗法鸡蛋膜敷料对伤口愈合的疗效。
在两项独立试验中，对14只雄性Sprague-Dawley大鼠制造全层切除伤口。每只动物在背部上方有2个伤口。一个伤口不进行处理，另一个伤口用鸡蛋膜覆盖，以评估其对伤口愈合的影响。一半的大鼠在下方伤口接受鸡蛋膜治疗，而另一半在上方伤口接受鸡蛋膜治疗。在实验的第5、8和10天进行膜更换、伤口清创和成像，然后在实验的第12、14、16、18和20天继续成像。根据实验20天内的伤口面积测量愈合率。
在愈合的早期阶段（第0至5天），与对照组相比，用鸡蛋膜覆盖的伤口愈合速度明显更快（P < 0.01）。在这个早期阶段，该组的愈合速度比对照组快21%。然而，总体而言，从第5天到第20天，伤口愈合率没有差异。
鸡蛋膜敷料在伤口愈合的早期阶段能显著促进皮肤伤口的愈合。
