Sridhar Susmita, Da Silva Anabela
Aix-Marseille Université, CNRS, Centrale Marseille, Institut Fresnel, UMR 7249, 13013 Marseille, FrancebInstitut de Ciències Fotòniques, Universitat Politècnica de Catalunya, 08860 Castelldefels, Barcelona, Spain.
Aix-Marseille Université, CNRS, Centrale Marseille, Institut Fresnel, UMR 7249, 13013 Marseille, France.
J Biomed Opt. 2016 Jul;21(7):71107. doi: 10.1117/1.JBO.21.7.071107.
Polarization gating is a popular and widely used technique in biomedical optics to sense superficial tissues (colinear detection), deeper volumes (crosslinear detection), and also selectively probe subsuperficial volumes (using elliptically polarized light). As opposed to the conventional linearly polarized illumination, we propose a new protocol of polarization gating that combines coelliptical and counter-elliptical measurements to selectively enhance the contrast of the images. This new method of eliminating multiple-scattered components from the images shows that it is possible to retrieve a greater signal and a better contrast for subsurface structures. In vivo experiments were performed on skin abnormalities of volunteers to confirm the results of the subtraction method and access subsurface information.
偏振选通是生物医学光学中一种常用且广泛应用的技术，用于检测浅表组织（共线检测）、较深组织区域（交叉线检测），还可选择性地探测皮下组织区域（使用椭圆偏振光）。与传统的线偏振照明不同，我们提出了一种新的偏振选通方案，该方案结合了共椭圆和反椭圆测量，以选择性地增强图像对比度。这种从图像中消除多重散射成分的新方法表明，对于地下结构，可以获得更强的信号和更好的对比度。对志愿者的皮肤异常情况进行了体内实验，以证实减法方法的结果并获取皮下信息。
