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复发性腮腺多形性腺瘤手术后的静止性面神经麻痹:丹麦1985 - 2012年219例病例的随访研究

Stationary facial nerve paresis after surgery for recurrent parotid pleomorphic adenoma: a follow-up study of 219 cases in Denmark in the period 1985-2012.

作者信息

Nøhr Anders, Andreasen Simon, Therkildsen Marianne Hamilton, Homøe Preben

机构信息

Department of Otolaryngology, Head and Neck Surgery 2073, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.

Department of Otorhinolaryngology and Maxillofacial Surgery, Køge University Hospital, Lykkebækvej 1, 4600, Køge, Denmark.

出版信息

Eur Arch Otorhinolaryngol. 2016 Oct;273(10):3313-9. doi: 10.1007/s00405-016-3921-9. Epub 2016 Feb 12.

Abstract

The purpose was to assess degree of permanent facial nerve dysfunction after surgery for recurrent pleomorphic adenoma (RPA) of the parotid gland, including variables that might influence re-operation outcomes. Nationwide retrospective longitudinal cohort study including a questionnaire survey of patients undergoing surgery for RPA. Of 219 living patients, 198 (92 %) responded and 127 (63 %) reported no facial dysfunction. Statistically significant associations were found between number of surgeries and permanent facial nerve dysfunction of all degrees (OR 1.43, 95 % CI 1.16-1.78, p = 0.001). A not significant tendency for females to be associated with worse outcome was found (p = 0.073). Risks of different degrees of paresis after the second-fourth surgeries were found (OR 1.86-2.19, p < 0.05). Our study demonstrates a significant correlation between number of surgeries for RPA of the parotid and severity of facial nerve paresis. This is important when informing and planning treatment of these patients.

摘要

目的是评估腮腺复发性多形性腺瘤(RPA)手术后永久性面神经功能障碍的程度,包括可能影响再次手术结果的变量。全国性回顾性纵向队列研究,包括对接受RPA手术患者的问卷调查。在219名在世患者中,198名(92%)做出回应,127名(63%)报告无面部功能障碍。手术次数与所有程度的永久性面神经功能障碍之间存在统计学显著关联(比值比1.43,95%置信区间1.16 - 1.78,p = 0.001)。发现女性预后较差的趋势不显著(p = 0.073)。发现第二次至第四次手术后不同程度轻瘫的风险(比值比1.86 - 2.19,p < 0.05)。我们的研究表明,腮腺RPA的手术次数与面神经轻瘫的严重程度之间存在显著相关性。这在为这些患者提供信息和规划治疗时很重要。

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