放射性食管炎的剂量测定和生物学预测指标的进展
Advances in dosimetry and biological predictors of radiation-induced esophagitis.
作者信息
Yu Yang, Guan Hui, Dong Yuanli, Xing Ligang, Li Xiaolin
机构信息
School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, Jinan, People's Republic of China.
Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong Province, People's Republic of China.
出版信息
Onco Targets Ther. 2016 Jan 28;9:597-603. doi: 10.2147/OTT.S97019. eCollection 2016.
OBJECTIVE
To summarize the research progress about the dosimetry and biological predictors of radiation-induced esophagitis.
METHODS
We performed a systematic literature review addressing radiation esophagitis in the treatment of lung cancer published between January 2009 and May 2015 in the PubMed full-text database index systems.
RESULTS
Twenty-eight eligible documents were included in the final analysis. Many clinical factors were related to the risk of radiation esophagitis, such as elder patients, concurrent chemoradiotherapy, and the intense radiotherapy regimen (hyperfractionated radiotherapy or stereotactic body radiotherapy). The parameters including Dmax, Dmean, V20, V30, V50, and V55 may be valuable in predicting the occurrence of radiation esophagitis in patients receiving concurrent chemoradiotherapy. Genetic variants in inflammation-related genes are also associated with radiation-induced toxicity.
CONCLUSION
Dosimetry and biological factors of radiation-induced esophagitis provide clinical information to decrease its occurrence and grade during radiotherapy. More prospective studies are warranted to confirm their prediction efficacy.
目的
总结放射性食管炎剂量学及生物学预测指标的研究进展。
方法
我们在PubMed全文数据库检索系统中对2009年1月至2015年5月发表的关于肺癌治疗中放射性食管炎的文献进行了系统综述。
结果
最终分析纳入了28篇符合条件的文献。许多临床因素与放射性食管炎风险相关，如老年患者、同步放化疗以及强烈放疗方案（超分割放疗或立体定向体部放疗）。包括Dmax、Dmean、V20、V30、V50和V55等参数可能对预测同步放化疗患者放射性食管炎的发生有价值。炎症相关基因的遗传变异也与放射诱导毒性有关。
结论
放射性食管炎的剂量学和生物学因素为降低放疗期间其发生率和严重程度提供了临床信息。需要更多前瞻性研究来证实它们的预测效力。
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