用于治疗恶性肿瘤的可生物降解的刺激响应性聚合物胶束
Biodegradable Stimuli-Responsive Polymeric Micelles for Treatment of Malignancy.
作者信息
Yan Lesan, Li Xingde
机构信息
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
出版信息
Curr Pharm Biotechnol. 2016;17(3):227-36. doi: 10.2174/138920101703160206142821.
In the past decade, drug delivery systems that can respond to the tumor microenvironment or external stimuli have emerged as promising platforms for treating malignancies due to their improved antitumor efficacy and reduced side effects. In particular, biodegradable polymeric micelles have attracted increasing attention and been rapidly developed as a distinct therapeutic to overcome limitations of conventional chemotherapeutic anticancer drugs. Because of their advantages with respect to biocompatibility, degradability, circulation time, and tumor accumulation, considerable effort has been dedicated to the developing and optimizing micellar systems during the past few years. This review highlights recent advances concerning stimuli-responsive micelles made of biodegradable polypeptide and polyester as nanocarries for drug delivery, and especially limits the content to pH sensitive, redox sensitive, and photo-sensitive micellar systems for safe and efficient cancer chemotherapy.
在过去十年中，能够响应肿瘤微环境或外部刺激的药物递送系统，因其提高的抗肿瘤疗效和减少的副作用，已成为治疗恶性肿瘤的有前景的平台。特别是，可生物降解的聚合物胶束已引起越来越多的关注，并作为一种独特的治疗方法迅速发展，以克服传统化疗抗癌药物的局限性。由于其在生物相容性、可降解性、循环时间和肿瘤蓄积方面的优势，在过去几年中人们投入了大量精力来开发和优化胶束系统。本综述重点介绍了由可生物降解的多肽和聚酯制成的刺激响应性胶束作为药物递送纳米载体的最新进展，尤其将内容限定为用于安全高效癌症化疗的pH敏感、氧化还原敏感和光敏感胶束系统。
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