Chothia C, Lesk A M, Tramontano A, Levitt M, Smith-Gill S J, Air G, Sheriff S, Padlan E A, Davies D, Tulip W R
MRC Laboratory of Molecular Biology, Cambridge, UK.
Nature. 1989;342(6252):877-83. doi: 10.1038/342877a0.
On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their subsequently determined structures.
基于对已知抗体结构和序列的比较研究，有人认为抗体六个高变区中至少五个的主链构象种类有限，且所采用的特定构象由少数几个关键保守残基决定。通过与随后确定的结构进行比较可知，目前这些假说得到了对各种抗体大多数高变区结构相当成功的预测的支持。
