Dua Anoushka, Narasimhalu Tara, Hamidi Sepehr, Dewan Rohit, Nulsen Benjamin
Department of Medicine, University of California Irvine, Orange, CA.
Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA.
ACG Case Rep J. 2025 Jun 5;12(6):e01717. doi: 10.14309/crj.0000000000001717. eCollection 2025 Jun.
Tumoral melanosis (TM) is a rare manifestation of a benign, completely regressed malignant melanoma and mimics malignant melanoma. These lesions are often found in patients with a history of known or undiscovered metastatic melanoma at or around areas of prior malignancy, commonly on the skin. We describe a rare case of TM discovered in the colon on routine screening colonoscopy in a patient with a history of metastatic melanoma who was responding well to systemic immunotherapy. The pigmented lesion, although endoscopically malignant-appearing, was found on histopathology to be a benign accumulation of melanin-laden macrophages, consistent with TM.
肿瘤性黑素沉着症（TM）是一种良性、完全消退的恶性黑色素瘤的罕见表现，类似恶性黑色素瘤。这些病变常出现在有已知或未发现的转移性黑色素瘤病史的患者中，位于先前恶性肿瘤部位或其周围，常见于皮肤。我们描述了一例罕见的TM病例，该病例是在一名有转移性黑色素瘤病史且对全身免疫治疗反应良好的患者进行常规结肠镜筛查时在结肠中发现的。尽管该色素沉着病变在内镜下看似恶性，但组织病理学检查发现是富含黑色素的巨噬细胞的良性聚集，符合TM。
