非结核分枝杆菌肺部感染的挑战
The Challenge of Pulmonary Nontuberculous Mycobacterial Infection.
作者信息
Novosad Shannon, Henkle Emily, Winthrop Kevin L
机构信息
Pulmonary & Critical Care Medicine Oregon Health & Science University 3181 SW Sam Jackson Park Road, UHN 67 Portland, OR, 97239 USA.
School of medicine Public Health & Preventive Medicine Oregon Health & Science University 3181 SW Sam Jackson Park Road Portland, OR, 97239 USA.
出版信息
Curr Pulmonol Rep. 2015 Sep 1;4(3):152-161. doi: 10.1007/s13665-015-0119-3. Epub 2015 Jul 12.
Abstract
The incidence of nontuberculous mycobacterial (NTM) lung disease is increasing. Current treatment strategies are largely based on expert opinion. The lack of randomized clinical trials to inform treatment leave clinicians with many questions regarding the most effective and safe regimens. The risk-benefit ratio of therapy is often thought to favor observation given the chronic nature of the disease, multiple long-term antibiotics recommended for therapy, side effects associated with treatment, and perceived lack of efficacious therapies.
摘要
非结核分枝杆菌（NTM）肺病的发病率正在上升。目前的治疗策略很大程度上基于专家意见。由于缺乏指导治疗的随机临床试验，临床医生对于最有效和安全的治疗方案存在诸多疑问。鉴于该疾病的慢性性质、治疗推荐使用多种长期抗生素、治疗相关的副作用以及人们认为缺乏有效治疗方法，通常认为治疗的风险效益比倾向于观察。
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