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头颈癌大手术后1至6个月期间,与生活质量结果改善相关的诊断和治疗特征。

Diagnostic and therapeutic features associated with modification of quality-of-life's outcomes between one and six months after major surgery for head and neck cancer.

作者信息

Gobbo Margherita, Bullo Federica, Perinetti Giuseppe, Gatto Annalisa, Ottaviani Giulia, Biasotto Matteo, Tirelli Giancarlo

机构信息

Dental Science Department, Division of Oral Medicine and Pathology, Trieste, Italy.

University of Trieste, Hospital of Cattinara, ENT Clinic, Head and Neck Department, Trieste, Italy.

出版信息

Braz J Otorhinolaryngol. 2016 Sep-Oct;82(5):548-57. doi: 10.1016/j.bjorl.2015.10.013. Epub 2015 Dec 18.

Abstract

INTRODUCTION

Treatments used in head and neck cancer greatly impact the physical, psychological and functional state of patients. Evaluation of quality of life has become an integral part of the treatment.

OBJECTIVE

This retrospective study evaluates features involved in changes in quality of life after major surgery for head and neck cancer within six months, according to self-reported outcomes.

METHODS

One hundred and thirty patients completed the University of Washington Quality of Life questionnaire one and six months after major surgery for head and neck cancer. A multivariate model was used to evaluate which diagnostic and therapeutic features were related to improvement of quality of life within a six-month period.

RESULTS

Significant improvement in most features related to quality of life was already recognizable at six months. Patients submitted to more invasive treatment had the biggest improvement in quality of life between time-points, as well as those patients with bigger tumors.

CONCLUSION

After major surgery, patients may undergo fast recovery, with overall quality of life likely to improve in the short-term. Clinicians must be aware of the importance of dealing with treatment-related issues immediately after surgery, with hopeful possibility of on-the-upgrade results.

摘要

引言

头颈癌的治疗方法对患者的身体、心理和功能状态有很大影响。生活质量评估已成为治疗的一个组成部分。

目的

本回顾性研究根据自我报告的结果,评估头颈癌大手术后六个月内生活质量变化所涉及的特征。

方法

130例患者在头颈癌大手术后1个月和6个月完成了华盛顿大学生活质量问卷。采用多变量模型评估哪些诊断和治疗特征与六个月内生活质量的改善有关。

结果

与生活质量相关的大多数特征在六个月时已有显著改善。接受更具侵入性治疗的患者在不同时间点之间生活质量改善最大,肿瘤较大的患者也是如此。

结论

大手术后,患者可能恢复迅速,短期内总体生活质量可能改善。临床医生必须意识到术后立即处理与治疗相关问题的重要性,有望取得越来越好的结果。

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