Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan.
Research Organization of Science and Technology, Ritsumeikan University, Japan.
Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3652-6. doi: 10.1002/anie.201511007. Epub 2016 Feb 16.
The direct oxidative coupling reaction has been an attractive tool for environmentally benign chemistry. Reported herein is that the hypervalent iodine catalyzed oxidative metal-free cross-coupling reaction of phenols can be achieved using Oxone as a terminal oxidant in 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP). This method features a high efficiency and regioselectivity, as well as functional-group tolerance under very mild reaction conditions without using metal catalysts.
直接氧化偶联反应一直是环境友好型化学的一种有吸引力的工具。本文报道了使用 Oxone 作为末端氧化剂，在 1,1,1,3,3,3-六氟-2-丙醇 (HFIP) 中，高价碘催化的酚的无金属氧化交叉偶联反应可以实现。该方法具有高效率和区域选择性，以及在非常温和的反应条件下对官能团的耐受性，无需使用金属催化剂。
