Shaviya Nathan, Budambula Valentine, Webale Mark K, Were Tom
Department of Medical Laboratory Sciences, Masinde Muliro University of Science and Technology, P.O. Box 190, Kakamega 50100, Kenya.
Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya.
Interdiscip Perspect Infect Dis. 2016;2016:9415364. doi: 10.1155/2016/9415364. Epub 2016 Jan 5.
Although interferon-gamma, interleukin-10, and adiponectin are key immunopathogenesis mediators of tuberculosis, their association with clinical manifestations of early stage disease is inconclusive. We determined interferon-gamma, interleukin-10, and adiponectin levels in clinically and phenotypically well-characterised non-substance using new pulmonary tuberculosis patients (n = 13) and controls (n = 14) from Kenya. Interferon-gamma levels (P < 0.0001) and interferon-gamma to interleukin-10 (P < 0.001) and interferon-gamma to adiponectin (P = 0.027) ratios were elevated in tuberculosis cases. Correlation analyses in tuberculosis cases showed associations of interferon-gamma levels with body weight (ρ = -0.849; P < 0.0001), body mass index (ρ = 0.664; P = 0.013), hip girth (ρ = -0.579; P = 0.038), and plateletcrit (ρ = 0.605; P = 0.028); interferon-gamma to interleukin-10 ratio with diastolic pressure (ρ = -0.729; P = 0.005); and interferon-gamma to adiponectin ratio with body weight (ρ = -0.560; P = 0.047), body mass index (ρ = -0.604; P = 0.029), and plateletcrit (ρ = 0.793; P = 0.001). Taken together, our results suggest mild-inflammation in early stage infection characterised by upregulation of circulating interferon-gamma production in newly infected TB patients.
尽管干扰素-γ、白细胞介素-10和脂联素是结核病关键的免疫发病机制介质，但它们与疾病早期临床表现的关联尚无定论。我们测定了来自肯尼亚的临床上和表型上特征明确的新发肺结核患者（n = 13）和对照组（n = 14）中干扰素-γ、白细胞介素-10和脂联素的水平。肺结核病例中干扰素-γ水平（P < 0.0001）以及干扰素-γ与白细胞介素-10的比值（P < 0.001）和干扰素-γ与脂联素的比值（P = 0.027）均升高。肺结核病例的相关性分析显示，干扰素-γ水平与体重（ρ = -0.849；P < 0.0001）、体重指数（ρ = 0.664；P = 0.013）、臀围（ρ = -0.579；P = 0.038）和血小板压积（ρ = 0.605；P = 0.028）相关；干扰素-γ与白细胞介素-10的比值与舒张压（ρ = -0.729；P = 0.005）相关；干扰素-γ与脂联素的比值与体重（ρ = -0.560；P = 0.047）、体重指数（ρ = -0.604；P = 0.029）和血小板压积（ρ = 0.793；P = 0.001）相关。综合来看，我们的结果表明，新感染肺结核患者早期感染存在轻度炎症，其特征是循环中干扰素-γ生成上调。
