一种来自蓝刺头根部的新型联噻吩。
A New Bithiophene from the Root of Echinops grijsii.
作者信息
Chang Fang-Pin, Chen Chien-Chih, Huang Hui-Chi, Wang Sheng-Yang, Chen Jih-Jung, Yang Chang-Syun, Ou Chung-Yi, Wu Jin-Bin, Huang Guan-Jhong, Kuo Yueh-Hsiung
出版信息
Nat Prod Commun. 2015 Dec;10(12):2147-9.
A new bithiophene, 5-(4-hydroxy-3-methoxy-1-butyny)-2,2'-bithiophene (1), and sixteen known thiophenes: 2-(3,4-dihydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (2), α-terthienyl (3), 5-(3,4-dihydroxybut-1-ynyl)-2,2'-bithiophene (4), 5-acetyl-2,2'-bithiophene (5), 5-formyl-2,2'-bithiophene (6), methyl 2,2'-bithiophene-5-carboxylate (7), 5-(but-3-en-1-ynyl)-2,2'-bithiophene (8), 5-(4-isovaleroyloxybut-1-ynyl)-2,2'-bithiophene (9), cardopatine (10), isocardopatine (11), 5-(3-hydroxy-4-isovaleroyloxybut-1-ynyl)-2,2'-bithiophene (12), 5-(3-hydroxymethyl-3-isovaleroyloxyprop-1-ynyl)-2,2'-bithiophene (13), 5-(4-hydroxy-1-butynyl)-2,2'-bithiophene (14), 5-(4-acetoxy-1-butynl)-2,2'-bithiophene (15), 2,2'-bithiophene-5-carboxylic acid (16) and 2-(4-hydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (17) were isolated from the roots of Echinops grjisii Hance. Among them, compounds 6, 7 and 16 were isolated from a natural source for the first time. Compounds 2, 4 and 14 exhibited significant anti-inflammatory activity against nitrite of LPS-stimulated production in the RAW 264.7 cell line.
从蓝刺头（Echinops grjisii Hance）的根部分离得到了一种新的联噻吩，即5-(4-羟基-3-甲氧基-1-丁炔基)-2,2'-联噻吩（1），以及十六种已知的噻吩：2-(3,4-二羟基丁-1-炔基)-5-(戊-1,3-二炔基)噻吩（2）、α-三联噻吩（3）、5-(3,4-二羟基丁-1-炔基)-2,2'-联噻吩（4）、5-乙酰基-2,2'-联噻吩（5）、5-甲酰基-2,2'-联噻吩（6）、2,2'-联噻吩-5-羧酸甲酯（7）、5-(丁-3-烯-1-炔基)-2,2'-联噻吩（8）、5-(4-异戊酰氧基丁-1-炔基)-2,2'-联噻吩（9）、卡多帕汀（10）、异卡多帕汀（11）、5-(3-羟基-4-异戊酰氧基丁-1-炔基)-2,2'-联噻吩（12）、5-(3-羟甲基-3-异戊酰氧基丙-1-炔基)-2,2'-联噻吩（13）、5-(4-羟基-1-丁炔基)-2,2'-联噻吩（14）、5-(4-乙酰氧基-1-丁炔基)-2,2'-联噻吩（15）、2,2'-联噻吩-5-羧酸（16）以及2-(4-羟基丁-1-炔基)-5-(戊-1,3-二炔基)噻吩（17）。其中，化合物6、7和16首次从天然来源中分离得到。化合物2、4和14对RAW 264.7细胞系中脂多糖刺激产生的亚硝酸盐具有显著的抗炎活性。
Zotero 插件