Bitew Helen, Hymete Ariaya
Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Front Pharmacol. 2019 Nov 1;10:1234. doi: 10.3389/fphar.2019.01234. eCollection 2019.
The genus belongs to the family of Asteraceae and comprises about 130 species. Many species belonging to the genus are traditionally used as medicinals mainly in Africa and Asia. The genus is reported to contain diverse secondary metabolites. The aim of this review is to critically evaluate the available research reports on the genus and systematically organize the findings. Information for this study was obtained using various search engines including PubMed and Google Scholar. This review revealed that the genus is used traditionally to treat pain, inflammation, respiratory diseases, diseases caused by different microorganisms, as an aphrodisiac, to fasten expulsion of placenta, and for removal of renal stones. More than 151 secondary metabolites have been reported from the genus in which thiophenic compounds held the biggest share. Various extracts, essential oils, and isolated compounds from members of this genus are shown to exhibit different biological effects mainly anti-microbial, anti-proliferative, and anti-inflammatory. However, there are a number of species in this genus that are claimed to have traditional medicinal uses but their biological effect not yet been evaluated.
该属属于菊科，约有130个物种。该属的许多物种传统上主要在非洲和亚洲被用作药物。据报道，该属含有多种次生代谢产物。本综述的目的是批判性地评估关于该属的现有研究报告，并系统地整理研究结果。本研究的信息是通过包括PubMed和谷歌学术在内的各种搜索引擎获得的。该综述表明，该属传统上用于治疗疼痛、炎症、呼吸系统疾病、由不同微生物引起的疾病、作为壮阳药、促进胎盘排出以及去除肾结石。该属已报道了151种以上的次生代谢产物，其中噻吩类化合物占比最大。该属成员的各种提取物、精油和分离出的化合物显示出不同的生物学效应，主要是抗菌、抗增殖和抗炎。然而，该属中有许多物种据称具有传统药用价值，但其生物学效应尚未得到评估。
