宽叶蓝刺头根部的二聚倍半萜和噻吩类化合物。
Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius.
作者信息
Jin Qinghao, Lee Jin Woo, Jang Hari, Choi Ji Eun, Kim Hyung Sik, Lee Dongho, Hong Jin Tae, Lee Mi Kyeong, Hwang Bang Yeon
机构信息
College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea; Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.
College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2016 Dec 15;26(24):5995-5998. doi: 10.1016/j.bmcl.2016.10.017. Epub 2016 Oct 18.
Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3-8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (H and C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.
对宽叶蓝刺头根部进行植物化学研究，分离得到一个新的具有碳骨架的二聚倍半萜（1）和一个新的噻吩（2），以及六个已知化合物（3 - 8）。通过光谱和波谱方法（氢谱和碳谱核磁共振、COSY、HSQC、HMBC、ROESY和质谱）阐明了它们的结构和相对立体化学。评估了所有分离物对RAW 264.7细胞中脂多糖诱导的一氧化氮产生的抑制作用。化合物4和5对一氧化氮的产生表现出最有效的抑制作用。
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