Xu LuHua, Jiang HongYan
Department of Otolaryngology-Head and Neck Surgery, Hainan Medical University Hainan Hospital, Haikou, 570311, China.
Head Face Med. 2025 Aug 7;21(1):56. doi: 10.1186/s13005-025-00532-7.
Noise-induced hearing loss (NIHL) is a major cause of hearing impairment globally, affecting numerous individuals. The pathogenesis of NIHL is complex, involving multiple mechanisms such as mechanical damage, oxidative stress, mitochondrial dysfunction, and energy metabolism disorders. Although these mechanisms are implicated, the complete understanding of NIHL's pathogenesis remains elusive. In recent years, the role of mitochondrial dysfunction and energy metabolism disorders in NIHL has garnered significant attention. This review aims to provide a comprehensive summary of the pathological mechanisms underlying NIHL, focusing on the contributions of mitochondrial damage and energy metabolism disorders. Moreover, this review evaluates existing therapeutic approaches and proposes future research directions through critical analysis of published evidence.
噪声性听力损失（NIHL）是全球听力障碍的主要原因，影响着众多人群。NIHL的发病机制复杂，涉及机械损伤、氧化应激、线粒体功能障碍和能量代谢紊乱等多种机制。尽管涉及这些机制，但对NIHL发病机制的全面理解仍然难以捉摸。近年来，线粒体功能障碍和能量代谢紊乱在NIHL中的作用受到了广泛关注。本综述旨在全面总结NIHL的病理机制，重点关注线粒体损伤和能量代谢紊乱的作用。此外，本综述通过对已发表证据的批判性分析，评估了现有的治疗方法并提出了未来的研究方向。
