修复后坐骨神经的生物力学特性：透明质酸或他克莫司局部应用的影响。
Biomechanical properties of the sciatic nerve following repair: effects of topical application of hyaluronic acid or tacrolimus.
作者信息
Mekaj Agon Y, Morina Arsim A, Lajqi Shpetim, Manxhuka-Kerliu Suzana, Kelmendi Fatos M, Duci Shkelzen B
机构信息
Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo.
Department of Construction and Mechanism, Faculty of Mechanical Engineering, University of Prishtina Bregu i Diellit p.n., Prishtina 10000, Kosovo.
出版信息
Int J Clin Exp Med. 2015 Nov 15;8(11):20218-26. eCollection 2015.
UNLABELLED
Recovery following nerve repair can be evaluated based on electrophysiological and morphological assessments of biomechanical properties. This study compared the effects of topical hyaluronic acid (HA), tacrolimus (FK-506) or saline administration on the biomechanical properties of the sciatic nerve at 12 weeks after nerve repair.
MATERIALS AND METHODS
Eighteen male European rabbits (Oryctolagus cuniculus) (weight from 2.5 to 3 kg) were randomly assigned to one of the following experimental groups (six animals per group): Saline, HA, or FK-506. The non-transected left leg was used as a control group (eighteen sciatic nerves). Biomechanical assays were performed and statistically analyzed.
RESULTS
The average maximal load, elastic limit load, maximal stress, and elastic limit strain of the control group were significantly different (P<0.001) from those of all three experimental groups. Moreover, the other examined parameters (i.e., maximal displacement, elastic limit stress, and maximal strain) were significantly different between the control group and all three experimental groups (P<0.0001). However, no significant differences in any of the biomechanical parameters were observed between the experimental groups (P>0.05). At 12 weeks after nerve repair, Saline, HA, and FK-506 groups displayed average maximal stress values that were 72.6%, 77.38%, and 73.8% of those in the control group (100%), respectively.
CONCLUSION
The biomechanical properties of the HA and FK-506 groups were similar to those of the saline group at 12 weeks after nerve repair.
未标记
神经修复后的恢复情况可通过对生物力学特性进行电生理和形态学评估来判断。本研究比较了局部应用透明质酸（HA）、他克莫司（FK-506）或生理盐水对神经修复后12周坐骨神经生物力学特性的影响。
材料与方法
18只雄性欧洲兔（穴兔）（体重2.5至3千克）被随机分配到以下实验组之一（每组6只动物）：生理盐水组、HA组或FK-506组。未横断的左腿用作对照组（18条坐骨神经）。进行生物力学测定并进行统计分析。
结果
对照组的平均最大负荷、弹性极限负荷、最大应力和弹性极限应变与所有三个实验组均有显著差异（P<0.001）。此外，对照组与所有三个实验组之间的其他检测参数（即最大位移、弹性极限应力和最大应变）也有显著差异（P<0.0001）。然而，实验组之间在任何生物力学参数上均未观察到显著差异（P>0.05）。在神经修复后12周，生理盐水组、HA组和FK-506组的平均最大应力值分别为对照组（100%）的72.6%、77.38%和73.8%。
结论
在神经修复后12周，HA组和FK-506组的生物力学特性与生理盐水组相似。
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