中东呼吸综合征冠状病毒受体在人类和单峰骆驼上呼吸道中的差异表达
Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels.
作者信息
Widagdo W, Raj V Stalin, Schipper Debby, Kolijn Kimberley, van Leenders Geert J L H, Bosch Berend J, Bensaid Albert, Segalés Joaquim, Baumgärtner Wolfgang, Osterhaus Albert D M E, Koopmans Marion P, van den Brand Judith M A, Haagmans Bart L
机构信息
Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
出版信息
J Virol. 2016 Apr 14;90(9):4838-4842. doi: 10.1128/JVI.02994-15. Print 2016 May.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.
摘要
中东呼吸综合征冠状病毒（MERS-CoV）在人与人之间传播效率不高，但在单峰骆驼中高度流行。我们在此报告，MERS-CoV受体——二肽基肽酶4（DPP4）——在骆驼的上呼吸道上皮中表达，而在人类上呼吸道上皮中不表达。缺乏DPP4表达可能是MERS-CoV在人类上呼吸道中复制受限并因此限制传播的主要原因。
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