Tang Siming, Ma Wanbiao, Bai Peifan
Department of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China.
Comput Math Methods Med. 2017;2017:5285810. doi: 10.1155/2017/5285810. Epub 2017 Aug 15.
The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.
中东呼吸综合征（MERS）冠状病毒是一种新发现的病原体，可导致人类严重肺炎。MERS由一种名为MERS-CoV的冠状病毒引起，该病毒攻击呼吸系统。最近确定的MERS-CoV受体二肽基肽酶4（DPP4）通常在内皮细胞和上皮细胞中表达，并且已证实在培养的人无纤毛细支气管上皮细胞中存在。本文给出了一类描述MERS-CoV感染的新型四维动力学模型，然后讨论了该模型平衡点的全局稳定性。我们的结果表明，降低DPP4的表达率也可以控制MERS-CoV的传播。
