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Glycation Reactivity of a Quorum-Sensing Signaling Molecule.群体感应信号分子的糖基化反应活性
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A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing.一种用于合成 4,5-二羟基-2,3-戊二酮（DPD）及其相关化合物的多功能策略，作为细菌群体感应的潜在调节剂。
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Ac2-DPD, the bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD) is a convenient stable precursor of bacterial quorum sensing autoinducer AI-2.Ac2-DPD，即4,5-二羟基-2,3-戊二酮（DPD）的双（O）-乙酰化衍生物，是细菌群体感应自诱导物AI-2的一种便捷稳定的前体。
Bioorg Med Chem Lett. 2007 Mar 1;17(5):1428-31. doi: 10.1016/j.bmcl.2006.11.076. Epub 2006 Dec 2.
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Deconvoluting interspecies bacterial communication.解析种间细菌通讯。
Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6314-5. doi: 10.1002/anie.201202440. Epub 2012 May 29.
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C4-alkoxy-HPD: a potent class of synthetic modulators surpassing nature in AI-2 quorum sensing.C4-烷氧基-HPD：一类强效的人工合成调节剂，在 AI-2 群体感应中超越了自然。
J Am Chem Soc. 2012 Aug 22;134(33):13562-4. doi: 10.1021/ja305532y. Epub 2012 Aug 9.
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Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: implications for a greater signaling diversity in bacterial species.通过核磁共振光谱揭示的未表征的4,5-二羟基-2,3-戊二酮（DPD）分子：对细菌物种中更大信号多样性的影响。
Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4204-8. doi: 10.1002/anie.201109149. Epub 2012 Feb 29.
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Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.肠道细菌中群体感应分子自诱导物-2的磷酸化与加工
ACS Chem Biol. 2007 Feb 20;2(2):128-36. doi: 10.1021/cb600444h. Epub 2007 Mar 2.
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A multivalent probe for AI-2 quorum-sensing receptors.一种用于 AI-2 群体感应受体的多价探针。
J Am Chem Soc. 2011 Oct 12;133(40):15934-7. doi: 10.1021/ja207556d. Epub 2011 Sep 15.
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Evaluation of Microparticulate (S)-4,5-Dihydroxy-2,3-pentanedione (DPD) as a Potential Vaccine Adjuvant.评估（S）-4,5-二羟基-2,3-戊二酮（DPD）作为一种潜在疫苗佐剂。
AAPS J. 2021 Jun 15;23(4):84. doi: 10.1208/s12248-021-00617-6.
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DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance.受 DPD 启发的新型 LsrK 激酶抑制剂的发现：对抗抗菌药物耐药性的新机会。
J Med Chem. 2019 Mar 14;62(5):2720-2737. doi: 10.1021/acs.jmedchem.9b00025. Epub 2019 Mar 4.
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Near-Infrared Light-Enhanced Protease-Conjugated Gold Nanorods As A Photothermal Antimicrobial Agent For Elimination Of Exotoxin And Biofilms.近红外光增强的蛋白酶偶联金纳米棒作为一种光热抗菌剂，用于消除外毒素和生物膜。
Int J Nanomedicine. 2019 Oct 4;14:8047-8058. doi: 10.2147/IJN.S212750. eCollection 2019.
本文引用的文献
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Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogues reveal distinct mechanisms for ligand recognition.LsrR 蛋白与磷酸化 AI-2 及两种信号阻断类似物复合物的晶体结构揭示了配体识别的不同机制。
J Am Chem Soc. 2013 Oct 16;135(41):15526-35. doi: 10.1021/ja407068v. Epub 2013 Oct 1.
2
Small molecule inhibitors of AI-2 signaling in bacteria: state-of-the-art and future perspectives for anti-quorum sensing agents.细菌中 AI-2 信号小分子抑制剂：用于抗群体感应剂的最新技术和未来展望。
Int J Mol Sci. 2013 Aug 29;14(9):17694-728. doi: 10.3390/ijms140917694.
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A "turn-on" fluorescent sensor for methylglyoxal.一种用于甲基乙二醛的“开启”型荧光传感器。
J Am Chem Soc. 2013 Aug 21;135(33):12429-33. doi: 10.1021/ja406077j. Epub 2013 Aug 9.
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A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level.一种在分子和细胞水平上探究群体感应调控行为的化学生物学方法。
Chem Biol. 2013 Jul 25;20(7):903-11. doi: 10.1016/j.chembiol.2013.05.009.
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Phosphoenolpyruvate phosphotransferase system regulates detection and processing of the quorum sensing signal autoinducer-2.磷酸烯醇丙酮酸磷酸转移酶系统调节群体感应信号自诱导物-2 的检测和处理。
Mol Microbiol. 2012 Apr;84(1):93-104. doi: 10.1111/j.1365-2958.2012.08010.x. Epub 2012 Mar 5.
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Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: implications for a greater signaling diversity in bacterial species.通过核磁共振光谱揭示的未表征的4,5-二羟基-2,3-戊二酮（DPD）分子：对细菌物种中更大信号多样性的影响。
Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4204-8. doi: 10.1002/anie.201109149. Epub 2012 Feb 29.
7
Large shifts in pKa values of lysine residues buried inside a protein.赖氨酸残基在蛋白质内部的 pKa 值发生大幅变化。
Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5260-5. doi: 10.1073/pnas.1010750108. Epub 2011 Mar 9.
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Synthetic analogs tailor native AI-2 signaling across bacterial species.合成类似物可调整不同细菌物种的内源性 AI-2 信号。
J Am Chem Soc. 2010 Aug 18;132(32):11141-50. doi: 10.1021/ja102587w.
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Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.定量蛋白质组学揭示树突状细胞中特定亚群的病毒识别。
Immunity. 2010 Feb 26;32(2):279-89. doi: 10.1016/j.immuni.2010.01.013. Epub 2010 Feb 18.
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Mutagenic potential of DNA glycation: miscoding by (R)- and (S)-N2-(1-carboxyethyl)-2'-deoxyguanosine.DNA 糖基化的诱变潜力：（R）-和（S）-N2-（1-羧乙基）-2'-脱氧鸟苷的错配编码。
Biochemistry. 2010 Mar 9;49(9):1814-21. doi: 10.1021/bi901924b.
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